Categories
Neurochecklists updates

30 recently revised and updated practical neurology checklists

Neurochecklists is proud of being comprehensive and practical.

But more than that, we take pride in keeping each checklist updated.

To do this, we keep a keen eye on all relevant developments in the literature.

And below are just a few of the checklists that we have recently revised.

They all reflect findings from the latest neurology publications.

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Anti Ma2 syndrome

Cerebral aneurysms rupture risk factors

Cerebral vein thrombosis

CGRP monoclonal antibodies

CJD

Dural AV fistula management

Giant cell arteritis treatment

Gluten sensitivity neurology

IIH clinical features

King-Denborough syndrome

Levetiracetam

Migraine acute treatment

MND c9orf72

Multiple sclerosis clinical features

Narcolepsy

Normal pressure hydrocephalus

Ocular myasthenia gravis

Oculopharyngeal muscular dystrophy

Ocrelizumab

Parkinson’s disease risk factors

Post stroke recrudescence

PSP variants

Psychogenic seizures

Rapid onset dystonia-parkinsonism

Retinal migraine

Seizure manifestations

Stiff person syndrome

Subacute combined degeneration

Suprascapular neuropathy

Thrombolysis

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Categories
Vasculitis

Is herpes zoster the cause of giant cell arteritis?

No detection of varicella-zoster virus in temporal arteries of patients with giant cell arteritis

Muratore F, Croci S, Tamagnini I, et al.

Semin Arthritis Rheum 2017; 47:235-240.

 

Abstract

Objective:

Data on the presence of varicella-zoster virus (VZV) in temporal arteries of patients with giant cell arteritis (GCA) are controversial. We analyzed VZV infection in temporal arteries from Italian patients with temporal artery biopsy (TAB)-positive GCA, TAB-negative GCA, and controls.

Methods:

A total of 79 formalin-fixed, paraffin-embedded (FFPE) TABs performed between 2009 and 2012 at a single institution from 34 TAB-positive GCA patients, 15 TAB-negative GCA patients, and 30 controls were retrieved. Six 5-μm sections of all FFPE TABs were cut. The first section was analyzed by immunohistochemistry using mouse monoclonal anti-VZVgE IgG1 antibody. DNA was extracted from the remaining five sections and analyzed by real-time polymerase chain reaction (PCR) for the presence of VZV DNA. For 10 of the 34 TAB-positive GCA patients, an additional 2-mm piece of frozen TAB was available. DNA was extracted from the entire 2-mm length frozen specimen and analyzed by PCR for the presence of VZV DNA. Thirty additional 5-μm sections were cut from the FFPE TABs of these 10 patients and analyzed by immunohistochemistry for the presence of VZV antigen.

Results:

Immunohistochemical analysis detected VZV antigen in 1/34 (3%) TAB-positive GCA, 0/15 TAB-negative GCA, and 0/30 controls, and in none of the 300 sections cut from the 10 FFPE TABs positive for GCA for which the frozen specimens were available. DNA obtained from all TABs was amplifiable. VZV DNA was neither found in any of the FFPE TABs nor found in frozen TABs.

Conclusion:

Our data do not support in Italian patients a possible role for VZV infection in the etiopathogenesis of GCA.

 


The following previous studies report an association between VZV and GCA

  • Gilden D, White T, Khmeleva N, Boyer PJ, Nagel MA. VZV in biopsy-positive and -negative giant cell arteritis: Analysis of 100+ temporal arteries. Neurol Neuroimmunol Neuroinflamm 2016; 3:e216.
  • Nagel MA, White T, Khmeleva N, et al. Analysis of varicella-zoster virus in temporal arteries biopsy positive and negative for giant cell arteritis. JAMA Neurol 2015; 72:1281-1287.

All three references are cited in the neurochecklist:

Giant cell arteritis (GCA): diagnosis and management

Abstract link 1

Abstract link 2

Abstract link 3

By Mikael HäggströmFile:Gray510.png, Public Domain, Link
Categories
Hydrocephalus Neurological error Spinal cord disorders Stroke

The 12 most hazardous neurological pitfalls…and their checklists

Neurology is a precarious specialty. Many neurological disorders are difficult to diagnose, and many neurological treatments are risky. Neurological error also leaves a high burden on patients, often resulting in death or permanent injury. It is therefore not surprising that the frequency and cost of neurological medical malpractice are high.

 

https://pixabay.com/en/hammer-books-law-court-lawyer-719066/

 

Neurology has the highest average indemnity payment of all specialties, and neurological malpractice cases are the most difficult to defend. The most common reason for neurological litigation is diagnostic error. This may manifest as wrong, missed, or delayed diagnosis. Diagnostic error is also responsible for the highest negligence payouts.

 

By Sven VolkensOwn work, CC BY-SA 4.0, Link

 

Neurological malpractice claims are often the result of incomplete or inaccurate neurological examination. Whilst neurologists and neurosurgeons bear the greatest burden of neurological malpractice cases, no group of doctors are immune from the frightening prospect of neurological medical negligence claims. Notable ‘victims’ include general physicians, orthopaedic surgeons, and emergency physicians. General practitioners are also at high risk of neurological negligence claims.

 

By Tracy Collins, CC BY-SA 2.0, Link

 

So what are the 12 high-stake, high-risk neurological diseases that threaten doctors and patients alike? Here they are…all linked to their safeguarding neurochecklists!

2. Stroke

4. Meningitis

8. Cervical artery dissection

9. Giant cell arteritis (GCA)

10. Multiple sclerosis (MS)

11. Epilepsy

12. Idiopathic intracranial hypertension (IIH) 

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Do you have any high-stake neurological pitfall not listed here? Then please leave a comment.