Is lasmiditan the next big thing in the fight against migraine?

Serotonin receptor targeted therapy for migraine treatment: an overview of drugs in phase I and II clinical development Barbanti P, Aurilia C, Egeo G, Fofi L, Palmirotta R. Expert Opin Investig Drugs 2017; 26:269-277. Abstract Background: Research has focused on serotonin (5-HT) 5-HT1D and 5-HT1F receptors to develop drugs acting through non-vasoconstrictive mechanisms for treating acute migraine… Read More Is lasmiditan the next big thing in the fight against migraine?

How often is the MRI normal following ischaemic stroke?

Diagnosis of DWI-negative acute ischemic stroke: a meta-analysis. Edlow BL, Hurwitz S, Edlow JA. Neurology 2017; 89:256-262. Abstract OBJECTIVE: To determine the prevalence of diffusion-weighted imaging (DWI)-negative acute ischemic stroke (AIS) and to identify clinical characteristics of patients with DWI-negative AIS. METHODS: We systematically searched PubMed and Ovid/MEDLINE for relevant studies between 1992, the year that the DWI sequence entered clinical… Read More How often is the MRI normal following ischaemic stroke?

Is herpes zoster the cause of giant cell arteritis?

No detection of varicella-zoster virus in temporal arteries of patients with giant cell arteritis Muratore F, Croci S, Tamagnini I, et al. Semin Arthritis Rheum 2017; 47:235-240.   Abstract Objective: Data on the presence of varicella-zoster virus (VZV) in temporal arteries of patients with giant cell arteritis (GCA) are controversial. We analyzed VZV infection in… Read More Is herpes zoster the cause of giant cell arteritis?

Do SSRIs contribute to mortality in epilepsy?

Serotonin reuptake inhibitors and mortality in epilepsy: a linked primary-care cohort study Josephson CB, Gonzalez-Izquierdo A, Denaxas S, et al. Epilepsia 2017; doi: 10.1111/epi.13904 (Epub ahead of print). Abstract OBJECTIVE: Preliminary evidence suggests that serotonin reuptake inhibitor (SRI) use may increase postictal respiratory drive and prevent death. We sought to determine whether SRIs are associated… Read More Do SSRIs contribute to mortality in epilepsy?

The 7 most ruthless bacterial infections of the nervous system

This is a follow up to our previous post, the 7 most devastating viral neurological infections. The list of bacteria that invade the nervous system is endless, but some stand out because of the fear they evoke, and the peril they pose. Here then are the 7 most horrifying bacterial infections that threaten the nervous… Read More The 7 most ruthless bacterial infections of the nervous system

Is head injury a risk factor for multiple sclerosis?

Concussion in adolescence and risk of multiple sclerosis Montgomery S, Hiyoshi A, Burkill S, Alfredsson L, Bahmanyar S, Olsson T. Ann Neurol 2017; 82:554-561 Abstract Objective: To assess whether concussion in childhood or adolescence is associated with subsequent multiple sclerosis (MS) risk. Previous research suggests an association, but methodological limitations included retrospective data collection and… Read More Is head injury a risk factor for multiple sclerosis?

What are the distinctive MRI features of myelopathy in Behcet’s syndrome?

Myelopathy in Behçet’s disease: the bagel sign Uygunoglu U, Zeydan B, Ozguler Y, et al. Ann Neurol 2017; 82:288-298. Abstract Objective: To describe the clinical and distinctive imaging features of myelopathy associated with Behçet’s disease (BD). Methods: We evaluated the records of patients meeting the following criteria: (1) fulfillment of the International Study Group criteria… Read More What are the distinctive MRI features of myelopathy in Behcet’s syndrome?