What is the impact of Vitamin D on the complicated course of MS?

Some general neurologists get away with not having to think too much about multiple sclerosis (MS). This is because they have an ‘MSologist‘ at hand to refer all their patients with ‘demyelination‘. Many general neurologists however care for people with MS because they do not have a ‘fallback guy‘ to do the heavy lifting for […]… Read More What is the impact of Vitamin D on the complicated course of MS?

Does rituximab really improve IgM anti-MAG neuropathy?

Long-term efficacy of rituximab in IgM anti-myelin-associated glycoprotein neuropathy: RIMAG follow-up study  Iancu Ferfoglia R, Guimarães-Costa R, Viala K, et al. J Peripher Nerv Syst 2016; 21:10-14 Abstract Background The Rituximab vs. Placebo in Polyneuropathy Associated With Anti-MAG IgM Monoclonal Gammopathy (RIMAG) study showed no improvement using the inflammatory neuropathy cause and treatment sensory score… Read More Does rituximab really improve IgM anti-MAG neuropathy?

Does simvastatin improve cognitive function in MS?

Effect of high-dose simvastatin on cognitive, neuropsychiatric, and health-related quality-of-life measures in secondary progressive multiple sclerosis: secondary analyses from the MS-STAT randomised, placebo-controlled trial. Chan D, Binks S, Nicholas JM, et al. Lancet Neurol 2017; 16:591-600. Abstract BACKGROUND: In the 24-month MS-STAT phase 2 trial, we showed that high-dose simvastatin significantly reduced the annualised rate of whole brain atrophy in patients with secondary progressive multiple sclerosis (SPMS). We now… Read More Does simvastatin improve cognitive function in MS?

Which neurological disorders respond to 3,4 diaminopyridine?

Aminopyridines for the treatment of neurologic disorders Strupp M, Teufel J, Zwergal A, Schniepp R, Khodakhah K, Feil K. Neurol Clin Pract 2017; 7:65-76 Abstract Purpose of review: To identify the different indications for the treatment of neurologic disorders with the potassium channel blockers 4-aminopyridine (4-AP) and 3,4-diaminopyridine (3,4-DAP). Recent findings: 4-AP is an effective… Read More Which neurological disorders respond to 3,4 diaminopyridine?

What does the upgoing thumb sign signify in suspected TIAs?

Upgoing thumb sign: a sensitive indicator of brain involvement? Hachinski V, Alsubaie R, Azarpazhooh MR Neurology 2017 (Epub ahead of print) Abstract OBJECTIVE: To assess the frequency of this finding in patients with minor stroke and TIAs compared to those with stroke mimics and to evaluate the level of agreement between examiners to detect an… Read More What does the upgoing thumb sign signify in suspected TIAs?

Where in the brain do musicogenic seizures arise from?

Localization of musicogenic epilepsy to Heschl’s gyrus and superior temporal plane: case report. Nagahama Y, Kovach CK, Ciliberto M, et al. J Neurosurg 2017; 15:1-8. Abstract Background: Musicogenic epilepsy (ME) is an extremely rare form of the disorder that is provoked by listening to or playing music, and it has been localized to the temporal… Read More Where in the brain do musicogenic seizures arise from?