What are the prospects of stem-cell gene therapy in adrenoleukodystrophy?

Hematopoietic stem-cell gene therapy for cerebral adrenoleukodystrophy Eichler F, Duncan C, Musolino PL, et al NEJM 2017; 377:1630-1638.   Abstract BACKGROUND: In X-linked adrenoleukodystrophy, mutations in ABCD1 lead to loss of function of the ALD protein. Cerebraladrenoleukodystrophy is characterized by demyelination and neurodegeneration. Disease progression, which leads to loss of neurologic function and death, can be halted only… Read More What are the prospects of stem-cell gene therapy in adrenoleukodystrophy?

What is the role of PET scanning in cerebral amyloid angiopathy?

Amyloid-PET in sporadic cerebral amyloid angiopathy: a diagnostic accuracy meta-analysis Charidimou A, Farid K, Baron JC. Neurology 2017; 89:1490-1498. Abstract OBJECTIVE: To perform a meta-analysis synthesizing evidence of the value and accuracy of amyloid-PET in diagnosing patients with sporadic cerebral amyloid angiopathy (CAA). METHODS: In a PubMed systematic literature search, we identified all case-control studies… Read More What is the role of PET scanning in cerebral amyloid angiopathy?

How does pregnancy influence the course of neuromyelitis optica?

High risk of postpartum relapses in neuromyelitis optica spectrum disorder Klawiter EC, Bove R, Elsone L, et al. Neurology 2017; (Epub ahead of print). Abstract OBJECTIVE: To study the effect of pregnancy on the frequency of neuromyelitis optica spectrum disorder (NMOSD) relapse and evaluate rates of pregnancy-related complications in an international multicenter setting. METHODS: We… Read More How does pregnancy influence the course of neuromyelitis optica?

How does serum potassium affect stroke risk and outcome?

Serum potassium is positively associated with stroke and mortality in the large, population-based malmö preventive project cohort. Johnson LS, Mattsson N, Sajadieh A, Wollmer P, Söderholm M Stroke 2017; 48:2973-2978.   Abstract BACKGROUND AND PURPOSE: Low serum potassium is associated with stroke in populations with cardiovascular disease, hypertension, and diabetes mellitus but has not been studied in a mainly healthy population. We… Read More How does serum potassium affect stroke risk and outcome?

200 dependable and reliable neurology patient support groups

Neurology is a jungle, and for the unwary, a minefield. It perhaps has the most diverse number of complex diseases of all the medical specialties. Patients are often bewildered by neurological processes and procedures, ranging from the probing questions to the bizarre examination ritual. They are dumbfounded by the variety of intricate tests required to assess just one symptom. The… Read More 200 dependable and reliable neurology patient support groups

What features distinguish subarachnoid haemorrhage in people with polycystic kidneys?

Polycystic kidney disease among 4,436 intracranial aneurysm patients from a defined population Nurmonen HJ, Huttunen T, Huttunen J, et al. Neurology 2017; 89:1852-1859. Abstract OBJECTIVE: To define the association of autosomal dominant polycystic kidney disease (ADPKD) with the characteristics of aneurysmal subarachnoid hemorrhage (aSAH) and unruptured intracranial aneurysm (IA) disease. METHODS: We fused data from… Read More What features distinguish subarachnoid haemorrhage in people with polycystic kidneys?

Could a diabetes medicine protect against dementia?

Metformin vs sulfonylurea use and risk of dementia in US veterans aged ≥65 years with diabetes Orkaby AR, Cho K, Cormack J, Gagnon DR, Driver JA. Neurology 2017; 89:1877-1885. Abstract OBJECTIVE: To determine whether metformin is associated with a lower incidence of dementia than sulfonylureas. METHODS: This was a retrospective cohort study of US veterans… Read More Could a diabetes medicine protect against dementia?