What does the MRI susceptibility vessel sign tells us about stroke subtypes?

Prediction of stroke subtype and recanalization using susceptibility vessel sign on susceptibility-weighted magnetic resonance imaging Kang DW, Jeong HG, Kim DY, Yang W, Lee SH. Stroke 2017; 48:1554-1559. Abstract BACKGROUND : The susceptibility vessel sign (SVS) is a hypointense signal visualized because of the susceptibility effect of thrombi, sensitively detected on susceptibility-weighted magnetic resonance imaging.… Read More What does the MRI susceptibility vessel sign tells us about stroke subtypes?

What does the upgoing thumb sign signify in suspected TIAs?

Upgoing thumb sign: a sensitive indicator of brain involvement? Hachinski V, Alsubaie R, Azarpazhooh MR Neurology 2017 (Epub ahead of print) Abstract OBJECTIVE: To assess the frequency of this finding in patients with minor stroke and TIAs compared to those with stroke mimics and to evaluate the level of agreement between examiners to detect an… Read More What does the upgoing thumb sign signify in suspected TIAs?

What is the risk of combining aspirin and clopidogrel following minor stroke?

Risks and benefits of clopidogrel-aspirin in minor stroke or TIA: Time course analysis of CHANCE Pan Y, Jing J, Chen W, et al; CHANCE investigators. Neurology 2017; 88:1906-1911. Abstract OBJECTIVE: To investigate the short-term time course risks and benefits of clopidogrel with aspirin in minor ischemic stroke or TIA. METHODS: Data were derived from the Clopidogrel in High-Risk Patients with… Read More What is the risk of combining aspirin and clopidogrel following minor stroke?

How does small vessel disease influence the outcome of stroke thrombolysis?

Small vessel disease and clinical outcomes after IV rt-PA treatment Arba F, Inzitari D, Ali M, Warach SJ, Luby M, Lees KR; STIR/VISTA Imaging Collaboration. Acta Neurol Scand 2017; 136:72-77. Abstract Introduction Cerebral small vessel disease (SVD) contributes to dementia and disability in the elderly, and may negatively affect stroke outcomes. We aimed to evaluate… Read More How does small vessel disease influence the outcome of stroke thrombolysis?

How often is the MRI normal following ischaemic stroke?

Diagnosis of DWI-negative acute ischemic stroke: a meta-analysis. Edlow BL, Hurwitz S, Edlow JA. Neurology 2017; 89:256-262. Abstract OBJECTIVE: To determine the prevalence of diffusion-weighted imaging (DWI)-negative acute ischemic stroke (AIS) and to identify clinical characteristics of patients with DWI-negative AIS. METHODS: We systematically searched PubMed and Ovid/MEDLINE for relevant studies between 1992, the year that the DWI sequence entered clinical… Read More How often is the MRI normal following ischaemic stroke?

Does thrombolysis add any value to mechanical thrombectomy after stroke?

Mechanical thrombectomy outcomes with and without intravenous thrombolysis in stroke patients: a meta-analysis. Mistry EA, Mistry AM, Nakawah MO, et al. Stroke 2017; 48:2450-2456. Abstract Background: Whether prior intravenous thrombolysis provides any additional benefits to the patients undergoing mechanical thrombectomy for large vessel, acute ischemic stroke remains unclear. Methods: We conducted a meta-analysis of 13 studies obtained through PubMed and EMBASE database searches to determine whether functional… Read More Does thrombolysis add any value to mechanical thrombectomy after stroke?

Do artificial sweeteners increase the risk of stroke and dementia?

Sugar and artificially sweetened beverages and the risks of incident stroke and dementia: a prospective cohort study. Pase MP, Himali JJ, Beiser AS, et al. Stroke 2017; 48:1139-1146. Abstract Background: Sugar- and artificially-sweetened beverage intake have been linked to cardiometabolic risk factors, which increase the risk of cerebrovascular disease and dementia. We examined whether sugar-… Read More Do artificial sweeteners increase the risk of stroke and dementia?