How often is the MRI normal following ischaemic stroke?

Diagnosis of DWI-negative acute ischemic stroke: a meta-analysis. Edlow BL, Hurwitz S, Edlow JA. Neurology 2017; 89:256-262. Abstract OBJECTIVE: To determine the prevalence of diffusion-weighted imaging (DWI)-negative acute ischemic stroke (AIS) and to identify clinical characteristics of patients with DWI-negative AIS. METHODS: We systematically searched PubMed and Ovid/MEDLINE for relevant studies between 1992, the year that the DWI sequence entered clinical… Read More How often is the MRI normal following ischaemic stroke?

Does thrombolysis add any value to mechanical thrombectomy after stroke?

Mechanical thrombectomy outcomes with and without intravenous thrombolysis in stroke patients: a meta-analysis. Mistry EA, Mistry AM, Nakawah MO, et al. Stroke 2017; 48:2450-2456. Abstract Background: Whether prior intravenous thrombolysis provides any additional benefits to the patients undergoing mechanical thrombectomy for large vessel, acute ischemic stroke remains unclear. Methods: We conducted a meta-analysis of 13 studies obtained through PubMed and EMBASE database searches to determine whether functional… Read More Does thrombolysis add any value to mechanical thrombectomy after stroke?

Do artificial sweeteners increase the risk of stroke and dementia?

Sugar and artificially sweetened beverages and the risks of incident stroke and dementia: a prospective cohort study. Pase MP, Himali JJ, Beiser AS, et al. Stroke 2017; 48:1139-1146. Abstract Background: Sugar- and artificially-sweetened beverage intake have been linked to cardiometabolic risk factors, which increase the risk of cerebrovascular disease and dementia. We examined whether sugar-… Read More Do artificial sweeteners increase the risk of stroke and dementia?

What is the outcome of thrombolysis for stroke of unknown onset time?

Intravenous thrombolysis in unknown-onset stroke: results from the safe implementation of treatment in Stroke-International Stroke Thrombolysis Registry. Dorado L, Ahmed N, Thomalla G, et al. Stroke 2017; 48:720-725. Abstract Background: Stroke patients with unknown onset (UKO) are excluded from thrombolytic therapy. We aim to study the safety and efficacy of intravenous alteplase in ischemic stroke… Read More What is the outcome of thrombolysis for stroke of unknown onset time?

Why is the diagnosis of cervical artery dissection difficult in older people?

CADISP-Plus Study Group. Cervical artery dissection in patients ≥60 years: often painless, few mechanical triggers Traenka C, Dougoud D, Simonetti BG, et al; Neurology 2017; 88:1313-1320. Abstract OBJECTIVE: In a cohort of patients diagnosed with cervical artery dissection (CeAD), to determine the proportion of patients aged ≥60 years and compare the frequency of characteristics (presenting… Read More Why is the diagnosis of cervical artery dissection difficult in older people?

What are the downsides of mechanical thrombectomy for stroke?

Thrombectomy for ischemic stroke: meta-analyses of recurrent strokes, vasospasms, and subarachnoid hemorrhages. Emprechtinger R, Piso B, Ringleb PA. J Neurol 2017; 264:432-436. Abstract Background: Mechanical thrombectomy with stent retrievers is an effective treatment for patients with ischemic stroke. Results of recent meta-analyses report that the treatment is safe. However, the endpoints recurrent stroke, vasospasms, and… Read More What are the downsides of mechanical thrombectomy for stroke?

How does alcohol affect the risk of intracerebral haemorrhage?

The following abstract is based on the Neurochecklist: Intracerebral haemorrhage (ICH): causes and risk factors Alcohol use and risk of intracerebral hemorrhage Chen CJ, Brown WM, Moomaw CJ, et al; ERICH Investigators. Neurology 2017; 88:2043-2051. Abstract OBJECTIVE: To analyze the dose-risk relationship for alcohol consumption and intracerebral hemorrhage (ICH) in the Ethnic/Racial Variations of Intracerebral Hemorrhage (ERICH) study. METHODS: ERICH is a… Read More How does alcohol affect the risk of intracerebral haemorrhage?