What are the neurological complications of anti-PD1 monoclonal antibodies?

Neurological complications associated with anti-programmed death 1 (PD-1) antibodies Kao JC, Liao B, Markovic SN, et al. JAMA Neurol 2017; 74:1216-1222. Abstract Importance: Neurological complications are an increasingly recognized consequence of the use of anti-programmed death 1 (PD-1) antibodies in the treatment of solid-organ tumors, with an estimated frequency of 4.2%. To date, the clinical spectrum and optimum treatment approach are not established.… Read More What are the neurological complications of anti-PD1 monoclonal antibodies?

Does the shape of the wrist affect the risk of carpal tunnel syndrome?

Association between wrist ratio and carpal tunnel syndrome: effect modification by body mass index Thiese MS, Merryweather A, Koric A, et al; Wistah Study Team. Muscle Nerve 2017; doi: 10.1002/mus.25692 (Epub ahead of print). Abstract Introduction: Previous studies have reported higher wrist ratios (WR) related to carpal tunnel syndrome (CTS) but have not assessed effect… Read More Does the shape of the wrist affect the risk of carpal tunnel syndrome?

What are the distinctive features of anti-neurofascin 155 antibody CIDP?

Cranial nerve hypertrophy in IgG4 anti-neurofascin 155 antibody-positive polyneuropathy. Franques J, Chapon F, Devaux J, Mathis S. Neurology 2017; 88:e52. Abstract Anti-NF155 IgG4 antibodies are associated with a younger age at onset, sensory ataxia, tremor, and a poor response to IVIg treatment. Nerve hypertrophy has been reported in up to half of patients with CIDP,… Read More What are the distinctive features of anti-neurofascin 155 antibody CIDP?

Is the HPV vaccine a cause of small fiber neuropathy?

Hypothesis: Human papillomavirus vaccination syndrome-small fiber neuropathy and dysautonomia could be its underlying pathogenesis. Martínez-Lavín M. Clin Rheumatol 2015; 34:1165-1169. ABSTRACT Hypothesis: Vaccination has been one of the most effective public health measures in the history of medicine. However, seemingly inexplicit adverse reactions have been described after the injection of the newer vaccines vs. human… Read More Is the HPV vaccine a cause of small fiber neuropathy?

Is tafamidis really beneficial in familial amyloid polyneuropathy?

Long-term treatment of transthyretin familial amyloid polyneuropathy with tafamidis: a clinical and neurophysiological study. Planté-Bordeneuve V, Gorram F, Salhi H, et al. J Neurol 2017; 264:268-276. ABSTRACT Background: Tafamidis is a transthyretin (TTR) stabilizer recently approved to slow the neurologic impairment in TTR familial amyloid polyneuropathy (TTR-FAP). The pivotal studies on Tafamidis reported encouraging results… Read More Is tafamidis really beneficial in familial amyloid polyneuropathy?

The 52 variants of CMT… and their practical checklists

Jean-Marie Charcot, Pierre Marie, and Howard Henry Tooth will be confounded to see what has become of the disease they described hundreds of years ago. Charcot-Marie Tooth disease (CMT) was a simple and straightforward disease then, with easily recognisable features such as the ‘classic’ high arched foot (pes cavus), the hammer toes, and the inverted champagne glass appearance of… Read More The 52 variants of CMT… and their practical checklists

How does CMT involve the central nervous system?

Cerebral white matter abnormalities in patients with Charcot-Marie-Tooth disease Lee M, Park CH, Chung HK, et al Ann Neurol 2017; 81:147-151 Abstract Here, we report the structural evidence of cerebral white matter abnormalities in Charcot-Marie-Tooth (CMT) patients and the relationship between these abnormalities and clinical disability. Brain diffusion tensor imaging (DTI) was performed in CMT… Read More How does CMT involve the central nervous system?