Is pruritus an important indicator of NMO?

Is pruritus an indicator of aquaporin-positive neuromyelitis optica? Netravathi M, Saini J, Mahadevan A, et al. Mult Scler 2017; 23:810-817. Abstract BACKGROUND: Recently, pruritus has been recognised as an important association with neuromyelitis optica spectrum disorders (NMOSD). RESULTS: Among 57 consecutive patients with NMOSD, 15 (26.3% women) reported pruritus. All had aquaporin-4 (AQP4) antibodies. The… Read More Is pruritus an important indicator of NMO?

How does gender influence neuromyelitis optica?

Influence of female sex and fertile age on neuromyelitis optica spectrum disorders Borisow N, Kleiter I, Gahlen A, et al; NEMOS (Neuromyelitis Optica Study Group) Mult Scler 2016; Epub ahead of print ABSTRACT Background: Gender and age at onset are important epidemiological factors influencing prevalence, clinical presentation, and treatment response in autoimmune diseases. Objective: To… Read More How does gender influence neuromyelitis optica?

What are the risks of rituximab in the treatment of neuromyelitis optica?

Efficacy and safety of rituximab therapy in neuromyelitis optica spectrum disorders: a systematic review and meta-analysis. Damato V, Evoli A, Iorio R. JAMA Neurol 2016; 73:1342-1348. Abstract IMPORTANCE: Neuromyelitis optica spectrum disorders (NMOSDs) are autoimmune astrocytopathies characterized by predominant involvement of the optic nerves and spinal cord. In most patients, an IgG autoantibody binding to… Read More What are the risks of rituximab in the treatment of neuromyelitis optica?