Does marriage improve survival in people with MND?

Marital status is a prognostic factor in amyotrophic lateral sclerosis Spataro R, Volanti P, Lo Coco D, La Bella V. Acta Neurol Scand 2017; doi: 10.1111/ane.12771 (Epub ahead of print). Abstract Background: Several variables have been linked to a shorter survival in patients with amyotrophic lateral sclerosis(ALS), for example, female sex, older age, site of disease… Read More Does marriage improve survival in people with MND?

Is farming a risk factor for motor neurone disease?

Farming and incidence of motor neuron disease: French nationwide study Kab S, Moisan F, Elbaz A Eur J Neurol 2017 (Epub ahead of print). Abstract BACKGROUND AND PURPOSE: The association of farming with motor neuron disease (MND) is unclear, with conflicting studies. We performed a French nationwide study of the association of farming with MND… Read More Is farming a risk factor for motor neurone disease?

Will edaravone improve the outcome of motor neurone disease?

Clinical efficacy of edaravone for the treatment of amyotrophic lateral sclerosis Sawada H Expert Opin Pharmacother 2017; 18:735-738. Abstract Introduction: Amyotrophic lateral sclerosis (ALS) is a progressive, fatal, neurodegenerative disease. Although the pathogenesis remains unresolved, oxidative stress is known to play a pivotal role. Edaravone works in the central nervous system as a potent scavenger… Read More Will edaravone improve the outcome of motor neurone disease?

What is the benefit of meditation training in MND?

Meditation training for people with amyotrophic lateral sclerosis: a randomized clinical trial. Pagnini F, Marconi A, Tagliaferri A, et al. Eur J Neurol 2017; 24:578-586. ABSTRACT Background: Studies investigating psychological interventions for the promotion of well-being in people with amyotrophic lateral sclerosis (ALS) are lacking. The purpose of the current study was to examine the… Read More What is the benefit of meditation training in MND?

Is motor neurone disease in HIV a treatable disorder?

 HIV-associated motor neuron disease. HERV-K activation and response to antiretroviral therapy Bowen LN, Tyagi R, Li W, et al. Neurology 2016; 87:1756-1762. Abstract OBJECTIVE: To determine whether there is activation of human endogenous retrovirus K (HERV-K) in amyotrophic lateral sclerosis in HIV infection and whether it might respond to treatment with antiretroviral drugs. METHODS: In… Read More Is motor neurone disease in HIV a treatable disorder?

What determines the poor prognosis of C9orf72 MND?

 C9orf72 expansion differentially affects males with spinal onset amyotrophic lateral sclerosis Rooney J, Fogh I, Westeneng HJ, et al. JNNP 2016; pii: jnnp-2016-314093 (Epub ahead of print). Abstract INTRODUCTION: The C9orf72 repeat expansion has been reported as a negative prognostic factor in amyotrophic lateral sclerosis (ALS). We have examined the prognostic impact of the C9orf72… Read More What determines the poor prognosis of C9orf72 MND?

How often does depression precede the onset of MND?

Depression in amyotrophic lateral sclerosis  Roos E, Mariosa D, Ingre C, et al. Neurology 2016; 86:2271-2277. Abstract OBJECTIVE: To examine the relative risk of depression among patients with amyotrophic lateral sclerosis (ALS), both in terms of depression diagnosis and use of antidepressant drugs, before and after diagnosis. METHODS: We conducted a nested case-control study including 1,752… Read More How often does depression precede the onset of MND?