Is lasmiditan the next big thing in the fight against migraine?

Serotonin receptor targeted therapy for migraine treatment: an overview of drugs in phase I and II clinical development Barbanti P, Aurilia C, Egeo G, Fofi L, Palmirotta R. Expert Opin Investig Drugs 2017; 26:269-277. Abstract Background: Research has focused on serotonin (5-HT) 5-HT1D and 5-HT1F receptors to develop drugs acting through non-vasoconstrictive mechanisms for treating acute migraine… Read More Is lasmiditan the next big thing in the fight against migraine?

The most unusual headache syndromes in neurology

Headaches constitute the bulk of what neurologists see in their general clinics. Most people with headaches fall neatly into one of two categories, migraine or tension type headache (TTH). The neurology clinic may have a sprinkling of people with cluster headache or paroxysmal hemicrania, two of the more common trigeminal autonomic cephalalgias (TACs). All these headaches are easy to recognise… Read More The most unusual headache syndromes in neurology

What is the influence of high altitude on migraine?

Migraine associated with altitude: results from a population-based study in Nepal. Linde M, Edvinsson L, Manandhar K, Risal A, Steiner TJ. Eur J Neurol 2017; 24:1055-1061. Abstract BACKGROUND AND PURPOSE: A 1988 pilot study in Peru suggested an association between migraine and chronic exposure to high altitude. This study provides epidemiological evidence corroborating this. METHODS: In a cross-sectional nationwide population-based study, a representative sample… Read More What is the influence of high altitude on migraine?

How does body weight influence the risk of migraine?

Body composition status and the risk of migraine: a meta-analysis Gelaye B, Sacco S, Brown WJ, Nitchie HL, Ornello R, Peterlin BL. Neurology 2017; 88:1795-1804. Abstract OBJECTIVE: To evaluate the association between migraine and body composition status as estimated based on body mass index and WHO physical status categories. METHODS: Systematic electronic database searches were… Read More How does body weight influence the risk of migraine?

What is the effect of venous sinus stenting for IIH?

Dural venous sinus stenting for medically and surgically refractory idiopathic intracranial hypertension Satti SR, Leishangthem L, Spiotta A, Chaudry MI. Interv Neuroradiol 2017; 23:186-193. Abstract Background: Idiopathic intracranial hypertension (IIH) is a syndrome defined by elevated intracranial hypertension without radiographic evidence of a mass lesion in the brain. Dural venous sinus stenosis has been increasingly… Read More What is the effect of venous sinus stenting for IIH?

Is migraine a risk factor for peri-operative stroke?

Migraine and risk of perioperative ischemic stroke and hospital readmission: hospital based registry study Timm FP, Houle TT, Grabitz SD, et al. BMJ 2017; 356:i6635. Abstract OBJECTIVE: To evaluate whether patients with migraine are at increased risk of perioperative ischemic stroke and whether this may lead to an increased hospital readmission rate. MAIN OUTCOME MEASURES:… Read More Is migraine a risk factor for peri-operative stroke?

Do oral contraceptives increase the risk of stroke in people with migraine?

Use of combined hormonal contraceptives among women with migraines and risk of ischemic stroke Champaloux SW, Tepper NK, Monsour M, et al. Am J Obstet Gynecol 2017; 216:489.e1-489.e7. Abstract BACKGROUND: Migraine with aura and combined hormonal contraceptives are independently associated with an increased risk of ischemic stroke. However, little is known about whether there are… Read More Do oral contraceptives increase the risk of stroke in people with migraine?