Does adolescent concussion predispose to multiple sclerosis?

Concussion in adolescence and the risk of multiple sclerosis: a retrospective cohort study.

Povolo CA, Reid JN, Shariff SZ, Welk B, Morrow SA.

Mult Scler 2020 (Epub ahead of print).

Abstract

BACKGROUND:

Physical trauma, specifically concussions sustained during adolescence, has been hypothesized to be a risk factor for multiple sclerosis (MS).

OBJECTIVE:

To examine the association between adolescent concussions and future MS diagnosis.

METHODS:

This retrospective study using linked administrative databases from Ontario, Canada, identified 97,965 adolescents (age 11-18 years) who sustained ⩾1 concussion and presented to an emergency department between 1992 and 2011. Cases were matched 1:3 with individuals who had not sustained a concussion based on age, sex, address, and index date. The primary outcome was MS diagnosis, using a validated MS diagnosis definition: ⩾1 hospitalization or ⩾5 physician billings within 2 years.

RESULTS:

concussion during adolescence was associated with a significantly increased risk of multiple sclerosis (hazard ratio (HR) = 1.29, p = 0.03). Sex-specific analysis revealed that only males who sustained a concussion in adolescence had a raised risk of MS (HR = 1.41, p = 0.04).

CONCLUSION:

This study supports an association between concussions in adolescence and future MS diagnoses, highlighting the potentially serious long-term effects of concussions.

This paper is cited in the neurochecklist:

Multiple sclerosis (MS): modifiable risk factors

MRI scan. NIH Image Gallery on Flikr. https://www.flickr.com/photos/nihgov/30754695411

Abstract link

Leave a Reply

Fill in your details below or click an icon to log in:

WordPress.com Logo

You are commenting using your WordPress.com account. Log Out /  Change )

Google photo

You are commenting using your Google account. Log Out /  Change )

Twitter picture

You are commenting using your Twitter account. Log Out /  Change )

Facebook photo

You are commenting using your Facebook account. Log Out /  Change )

Connecting to %s