Is smoking a risk factor for motor neurone disease?

Smoking and amyotrophic lateral sclerosis: a mendelian randomization study.

Zhan Y, Fang F

Ann Neurol 2019; 85:482-484.

Abstract

Background:

In this study, we examined the potential causal effect of smoking on amyotrophic lateral sclerosis (ALS) using the Project MinE data involving 12,577 patients with ALS and 23,475 controls in a Mendelian randomization (MR) framework.

Methodology:

The MR approach has the potential to investigate a causal relationship between a risk factor and a disease, avoiding confounding and information bias that often present in conventional epidemiological studies.

Results:

We found that smokers had a higher risk of ALS compared to never smokers.

Conclusions:

Our study thus provides evidence for a causal relationship between smoking and ALS.

This reference is cited in the neurochecklist:

Motor neurone disease (MND): environmental risk factors

Smoking Tobacco Cigarette. Lindsay Fox on Flickr. https://www.flickr.com/photos/87735223@N02/25841963510

Abstract link

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