Should people with myotonic dystrophy be counselled on the risk of cancer?

A population-based survey of risk for cancer in individuals diagnosed with myotonic dystrophy

Abbott D, Johnson NE, Cannon-Albright LA

Muscle Nerve 2016; 54:783-785.

Abstract

Introduction:

The risk of cancer in patients diagnosed with myotonic dystrophy (DM) is reported for the homogeneous Utah population.

Methods:

Clinical data accessed from the largest Utah healthcare providers have been record-linked to the Utah Population Database, a population-based resource also linked to the Utah Cancer Registry. Relative risks were estimated for 36 cancers of different types in 281 DM patients.

Results:

Testicular cancer (relative risk [RR] = 10.74; 95% confidence interval [CI], 1.91-38.79), endometrial cancer (RR = 6.98; 95% CI, 1.24-25.22), and non-Hodgkin lymphoma (RR = 4.25; 95% CI, 1.16-12.43) were all observed at significant excess in DM patients.

Conclusions:

This study confirms an overall increased risk of cancer in DM. Individuals diagnosed with DM might benefit from risk counseling.

This reference is cited in the neurochecklist:

Myotonic dystrophy type 1: management

Abstract link

By National Center for Biotechnology Information – NCBI Bookshelf “Genes and Disease” (1998-). Available from: http://www.ncbi.nlm.nih.gov/books/NBK22266/, Public Domain, Link
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