The innovative treatments relieving the burden of people with multiple sclerosis

The drug armoury for multiple sclerosis (MS) is ever-expanding. This topic has been extensively covered by our sister blog, The Neurology Lounge, in the blog posts titled:

 Which are the remarkable drugs which have transformed the treatment of MS

Multiple sclerosis treatment: new kids on the block

The emerging progress from the world of MS

How good is ocrelizumab for primary progressive MS

By Marvin 101Own work, CC BY-SA 3.0, Link

This blog post lists all the current MS disease modifying therapies (DMTs), with links to their Neurochecklist page. Each checklist gives a comprehensive summary of mode of action, dosing, side effects, monitoring indices, and precautions. Here they are:

DMTs for mild disease

Interferons

Glatiramer acetate

Terifluonomide

Dimethyl fumarate

By Marvin 101Kazi yangu, CC BY-SA 3.0, Link

DMTs for aggressive disease

Fingolimod

Natalizumab

Alemtuzumab

By Roman H. Khonsari, Vincent Calvez – The Origins of Concentric Demyelination: Self-Organization in the Human Brain. Roman H. Khonsari and Vincent Calvez PLoS ONE. 2007; 2(1): e150. [1], CC BY 1.0, Link

Second line DMTs for aggressive disease

Cladribine

Mitoxantrone

Cyclophosphamide

Haematopoeitic stem cell transplant (HSCT)

By Ryddragyn at English Wikipedia – Transferred from en.wikipedia to Commons., Public Domain, Link


Because the work is never done with MS, we also list the emerging DMTs that will shape MS practice in the near future.

Monoclonal antibodies

Rituximab

Ofatumumab

By Oguenther at de.wikipediaOwn work mit Jmol auf Basis RCSB PDB: 2OSL​., Public Domain, Link

Sphingosin-1-phosphate receptor modulators

Ozanimod

Siponimod

Amiselimod

MD1003 (high dose biotin)

Laquinimod

Ponesimod

Ceralifimod

By Jynto (talk) – Own workThis chemical image was created with Discovery Studio Visualizer., CC0, Link

Phosphodiesterase inhibitors

Ibudilast

Tyrosine 1 kinase inhibitors

Masitinib

 

Boghog自己的作品CC BY-SA 3.0链接
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