Cranial nerve hypertrophy in IgG4 anti-neurofascin 155 antibody-positive polyneuropathy.
Franques J, Chapon F, Devaux J, Mathis S.
Neurology 2017; 88:e52.
Anti-NF155 IgG4 antibodies are associated with a younger age at onset, sensory ataxia, tremor, and a poor response to IVIg treatment. Nerve hypertrophy has been reported in up to half of patients with CIDP, particularly in anti-NF155 antibody-positive patients. Hypertrophy of cervical and lumbosacral roots/plexuses has also been observed. Neurologists should be aware that patients with CIDP and anti-NF155 antibodies may demonstrate diffuse cranial nerve hypertrophy.