What are the distinctive features of anti-neurofascin 155 antibody CIDP?

Cranial nerve hypertrophy in IgG4 anti-neurofascin 155 antibody-positive polyneuropathy.

Franques J, Chapon F, Devaux J, Mathis S.

Neurology 2017; 88:e52.


Anti-NF155 IgG4 antibodies are associated with a younger age at onset, sensory ataxia, tremor, and a poor response to IVIg treatment. Nerve hypertrophy has been reported in up to half of patients with CIDP, particularly in anti-NF155 antibody-positive patients. Hypertrophy of cervical and lumbosacral roots/plexuses has also been observed. Neurologists should be aware that patients with CIDP and anti-NF155 antibodies may demonstrate diffuse cranial nerve hypertrophy.

This reference is included in the neurochecklist:

Chronic inflammatory demyelinating polyradiculoneuropathy (CIDP): investigations

Abstract link

By Dr. Jana – http://docjana.com/saltatory-conduction/ ; https://www.patreon.com/posts/4374048, CC BY 4.0, Link

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