What are the drugs in development for the treatment of epilepsy?

Progress report on new antiepileptic drugs: a summary of the Thirteenth Eilat Conference on New Antiepileptic Drugs and Devices (EILAT XIII)

Bialer M, Johannessen SI, Levy RH, Perucca E, Tomson T, White HS

Epilepsia 2017; doi: 10.1111/epi.13634 (Epub ahead of print)

Abstract

The Thirteenth Eilat Conference on New Antiepileptic Drugs and Devices (EILAT XIII) took place in Madrid, Spain, on June 26-29, 2016, and was attended by >200 delegates from 31 countries. The present Progress Report provides an update on experimental and clinical results for drugs presented at the Conference.

Compounds for which summary data are presented include an AED approved in 2016 (brivaracetam), 12 drugs in phase I-III clinical development (adenosine, allopregnanolone, bumetanide, cannabidiol, cannabidivarin, 2-deoxy-d-glucose, everolimus, fenfluramine, huperzine A, minocycline, SAGE-217, and valnoctamide) and 6 compounds or classes of compounds for which only preclinical data are available (bumetanide derivatives, sec-butylpropylacetamide, FV-082, 1OP-2198, NAX 810-2, and SAGE-689).

Overall, the results presented at the Conference show that considerable efforts are ongoing into discovery and development of AEDs with potentially improved therapeutic profiles compared with existing agents.

Many of the drugs discussed in this report show innovative mechanisms of action and many have shown promising results in patients with pharmacoresistant epilepsies, including previously neglected rare and severe epilepsy syndromes.

This reference is now included in the neurochecklist:

Antiepileptic drugs (AEDs): types by metabolism

Abstract link

Cocktail of drugs. Phillppa Willitts on Flikr. https://www.flickr.com/photos/hippie/2563571511
Cocktail of drugs. Phillppa Willitts on Flikr. https://www.flickr.com/photos/hippie/2563571511
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