The 29 proven anti-epilepsy drugs…and their practical checklists

Epilepsy is a big problem for Neurology. It is a common, and often life-long, disease. Epilepsy is like the mythical hydra in its diverse manifestations, and in its duplicitous evasion of treatment.

By http://wellcomeimages.org/indexplus/obf_images/5c/4e/30eb7506272a7b448f0f1f22ae63.jpgGallery: http://wellcomeimages.org/indexplus/image/L0011685.html, CC BY 4.0, Link
By http://wellcomeimages.org/indexplus/obf_images/5c/4e/30eb7506272a7b448f0f1f22ae63.jpgGallery: http://wellcomeimages.org/indexplus/image/L0011685.html, CC BY 4.0, Link

The pillars of epilepsy treatment are the anti-epileptic drugs (AEDs). It is however a very tricky business to wield these very powerful tools. For example, one epilepsy medication may work wonders for one form of the epilepsy, and make another type much worse.

Cocktail of drugs. Phillppa Willitts on Flikr. https://www.flickr.com/photos/hippie/2563571511
Cocktail of drugs. Phillppa Willitts on Flikr. https://www.flickr.com/photos/hippie/2563571511

Any successful anti-epilepsy regime must therefore be carefully thought through, requiring a strategy that keeps the following key issues in mind all the time:

  • Mode of action
  • Indications
  • Dosing
  • Side effects
  • Interaction with other drugs
  • Teratogencity

With these in mind, neurochecklists explored the difficult terrain, and came up with comprehensive, but concise, checklists for the 29 essential anti-epilepsy drugs. What better way to navigate the choppy waters of epilepsy treatment? To help chart the course, here they are, in alphabetical order.

Acetazolamide

Brivaracetam

Carbamazepine

Clobazam

Clonazepam

*

Eslicarbazepine

Ethosuximide

Everolimus

Felbamate

Gabapentin

*

Lacosamide

Lamotrigine

Levetiracetam

Oxcarbazepine

Perampanel

*

Phenobarbitone

Phenytoin

Piracetam

Pregabalin

Primidone

*

Retigabine

Rufinamide

Stiripentol

Sulthiame

Tiagabine

*

Topiramate

Valproate

Vigabatrin

Zonisamide

***

Don’t forget, all the checklists are fully referenced, and linked to their PubMed abstracts. Go on then, explore!

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