Is motor neurone disease in HIV a treatable disorder?

 HIV-associated motor neuron disease. HERV-K activation and response to antiretroviral therapy

Bowen LN, Tyagi R, Li W, et al.

Neurology 2016; 87:1756-1762.

Abstract

OBJECTIVE:

To determine whether there is activation of human endogenous retrovirus K (HERV-K) in amyotrophic lateral sclerosis in HIV infection and whether it might respond to treatment with antiretroviral drugs.

METHODS:

In this case series, we present 5 patients with HIV infection who subsequently developed motor neuron disease involving both upper and lower motor neurons. We monitored HERV-K levels in plasma of 4 of these patients.

RESULTS:

Three patients who received antiretroviral therapy had reversal of symptoms within 6 months of onset of neurologic symptoms and the other 2 had slow neurologic progression over several years. Three patients in whom the levels were measured at onset of neurologic symptoms showed elevated HERV-K levels that responded to optimization of antiretroviral therapy for CNS penetration.

CONCLUSIONS:

Thus, motor neuron disease in individuals with HIV infection may a treatable entity, but early treatment with CNS-penetrating antiretroviral therapy may be necessary. Monitoring of HERV-K levels may help guide treatment.

This reference is now included in the neurochecklists:

Motor neurone disease (MND): risk factors

HIV associated neurological infections

 

screen-shot-2016-12-24-at-23-32-53

Abstract link

By US National Institute of Health (redrawn by en:User:Carl Henderson) - US National Institute of Health (redrawn by en:User:Carl Henderson)http://web.archive.org/web/20050531012945/http://www.niaid.nih.gov/factsheets/howhiv.htmhttp://web.archive.org/web/20041119131214/http://www.niaid.nih.gov/factsheets/graphics/howhiv.jpg, Public Domain, Link
By US National Institute of Health (redrawn by en:User:Carl Henderson) – US National Institute of Health (redrawn by en:User:Carl Henderson)http://web.archive.org/web/20050531012945/http://www.niaid.nih.gov/factsheets/howhiv.htmhttp://web.archive.org/web/20041119131214/http://www.niaid.nih.gov/factsheets/graphics/howhiv.jpg, Public Domain, Link
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4 thoughts on “Is motor neurone disease in HIV a treatable disorder?

  1. Exhaustive evaluation and work up is required for diffrent potentially reversible motor neuron syndromes such as viral infections, Neurosyphilis, metabolic disorders before embarking on the diagnosis of ALS.

    Like

  2. Hi Sir,

    Can you please help me, as my dad is in serious stage who is suffering from HIV-2 with MND

    Please share your inputs

    Current medication:
    Rilutor
    Vitamin D
    Pain killers
    Duovir
    Lopimune

    Like

    1. Dear Harish. I’m sorry about your dad. Unfortunately I am unable to give any person-specific advice via this blog. I’m sure his neurologist will be in a good position to do this. Best wishes

      Like

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