What has hepatitis C virus to do with Parkinson’s disease?

Hepatitis C virus infection as a risk factor for Parkinson disease: a nationwide cohort study

Tsai HH, Liou HH, Muo CH, Lee CZ, Yen RF, Kao CH.

Neurology 2016; 86:840-846.

Abstract

 OBJECTIVE:

To determine whether hepatitis C virus (HCV) infection is a risk factor for developing Parkinson disease (PD).

METHODS:

This nationwide population-based cohort study was based on data obtained from a dataset of the Taiwan National Health Insurance Research Database for the period 2000 to 2010. A total of 49,967 patients with viral hepatitis were included for analysis. Furthermore, 199,868 people without viral hepatitis were included for comparisons. Patients with viral hepatitis were further grouped into 3 cohorts: hepatitis B virus (HBV) infection, HCV infection, and HBV-HCV coinfection. In each cohort, we calculated the incidence of developing PD. A Cox proportional hazards model was applied to estimate the risk of developing PD in terms of hazard ratios (HRs) and 95% confidence intervals (CIs).

RESULTS:

The crude HRs for developing PD was 0.66 (95% CI = 0.55-0.80) for HBV infection, 2.50 (95% CI = 2.07-3.02) for HCV infection, and 1.28 (95% CI = 0.88-1.85) for HBV-HCV coinfection. The association between HCV and PD remained statistically significant after adjustments for age, sex, and comorbidities (adjusted HR = 1.29, 95% CI = 1.06-1.56).

CONCLUSIONS:

We conducted a large nationwide population-based study and found that patients with HCV exhibit a significantly increased risk of developing PD.

You may also check out

Hepatitis C virus infection: a risk factor for Parkinson’s disease.

Wu WY, Kang KH, Chen SL, et al.

J Viral Hepat 2015; 22:784-791.

These references are now included in the Neurochecklist:

Hepatitis C virus (HCV) neurology

Parkinson’s disease (PD): risk factors

screen-shot-2016-12-24-at-23-32-53

Abstract link

By BruceBlaus - Own work, CC BY-SA 4.0, Link
By BruceBlausOwn work, CC BY-SA 4.0, Link
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