What is the status of high dose biotin in the treatment of MS?

MD1003 (high-dose biotin) for the treatment of progressive multiple sclerosis: A randomised, double-blind, placebo-controlled study

Tourbah A, Lebrun-Frenay C, Edan G, et al; MS-SPI study group.

Mult Scler 2016; 22:1719-1731

Abstract

BACKGROUND:

Treatment with MD1003 (high-dose biotin) showed promising results in progressive multiple sclerosis (MS) in a pilot open-label study.

OBJECTIVE:

To confirm the efficacy and safety of MD1003 in progressive MS in a double-blind, placebo-controlled study.

METHODS:

Patients (n = 154) with a baseline Expanded Disability Status Scale (EDSS) score of 4.5-7 and evidence of disease worsening within the previous 2 years were randomised to 12-month MD1003 (100 mg biotin) or placebo thrice daily, followed by 12-month MD1003 for all patients. The primary endpoint was the proportion of patients with disability reversal at month 9, confirmed at month 12, defined as an EDSS decrease of ⩾1 point (⩾0.5 for EDSS 6-7) or a ⩾20% decrease in timed 25-foot walk time compared with the best baseline among screening or randomisation visits.

RESULTS:

A total of 13 (12.6%) MD1003-treated patients achieved the primary endpoint versus none of the placebo-treated patients (p = 0.005). MD1003 treatment also reduced EDSS progression and improved clinical impression of change compared with placebo. Efficacy was maintained over follow-up, and the safety profile of MD1003 was similar to that of placebo.

CONCLUSION:

MD1003 achieves sustained reversal of MS-related disability in a subset of patients with progressive MS and is well tolerated.

This reference is now included in the neurochecklist:

Multiple sclerosis MS: emerging treatments

screen-shot-2016-12-24-at-23-32-53

Abstract link

By Fdardel - Own work, CC BY-SA 3.0, Link
By FdardelOwn work, CC BY-SA 3.0, Link
Advertisements

Leave a Reply

Fill in your details below or click an icon to log in:

WordPress.com Logo

You are commenting using your WordPress.com account. Log Out / Change )

Twitter picture

You are commenting using your Twitter account. Log Out / Change )

Facebook photo

You are commenting using your Facebook account. Log Out / Change )

Google+ photo

You are commenting using your Google+ account. Log Out / Change )

Connecting to %s