The Neurology Lounge strives hard to keep to the straight and narrow path of clinical neurology. But every now and then it takes a peek at what is happening at the cutting edge of neuroscience. And what can be more cutting edge then biomarkers, with their promise of simplifying disease identification, making prompt and accurate… Read More What are the promising CSF biomarkers of MND?
Neurochecklists has one goal… To simplify access to neurology. So we are always keen to know… About how you access neurology information… And how you make sense of it all. What are your expectations? What challenges do you face? What frustrations do you encounter? We are exploring these questions… Because we are undertaking a major upgrade. So we have devised a very short survey.… Read More Ease of access to neurology: the ultimate survey
Intracellular and non-neuronal targets of voltage-gated potassium channel complex antibodies Lang B, Makuch M, Moloney T, et al. JNNP 2017; 88:353-361. Abstract Objectives: Autoantibodies against the extracellular domains of the voltage-gated potassium channel (VGKC) complex proteins, leucine-rich glioma-inactivated 1 (LGI1) and contactin-associated protein-2 (CASPR2), are found in patients with limbic encephalitis, faciobrachial dystonic seizures, Morvan’s… Read More What is the significance of double negative VGKC antibodies?
Aspirin versus placebo in pregnancies at high risk for preterm preeclampsia. Rolnik DL, Wright D, Poon LC, et al. N Engl J Med 2017; 377:613-622. Abstract BACKGROUND: Preterm preeclampsia is an important cause of maternal and perinatal death and complications. It is uncertain whether the intake of low-dose aspirin during pregnancy reduces the risk of preterm preeclampsia. METHODS: In this multicenter, double-blind, placebo-controlled trial, we… Read More Is aspirin effective in the prevention of preeclampsia?
Clinicoradiologic features distinguish tumefactive multiple sclerosis from CNS neoplasms Lin X, Yu W-Y, Liauw L, et al. Neurol Clin Pract 2017; 7:53-64. Abstract Background: There are limited data to guide clinicians in differentiating tumefactive multiple sclerosis (TMS) from CNS neoplasms. Identifying distinguishing features will inform diagnosis and management and avoid unnecessary diagnostic biopsy. Our study… Read More What MRI features differentiate tumefactive MS from brain tumours?
Brain-responsive neurostimulation in patients with medically intractable mesial temporal lobe epilepsy Geller EB, Skarpaas TL, Gross RE, et al. Epilepsia 2017; 58:994-1004. Abstract OBJECTIVE: Evaluate the seizure-reduction response and safety of mesial temporal lobe (MTL) brain-responsive stimulation in adults with medically intractable partial-onset seizures of mesial temporal lobe origin. METHODS: Subjects with mesial temporal lobe… Read More How effective is brain responsive neurostimulation for intractable epilepsy?
Prediction of stroke subtype and recanalization using susceptibility vessel sign on susceptibility-weighted magnetic resonance imaging Kang DW, Jeong HG, Kim DY, Yang W, Lee SH. Stroke 2017; 48:1554-1559. Abstract BACKGROUND : The susceptibility vessel sign (SVS) is a hypointense signal visualized because of the susceptibility effect of thrombi, sensitively detected on susceptibility-weighted magnetic resonance imaging.… Read More What does the MRI susceptibility vessel sign tells us about stroke subtypes?